Needling and open filtering bleb revision after XEN-45 implantation—a retrospective outcome comparison

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5.1. Intraoperative use and needling bleb revision with mitomycin C Intraoperative use and needling bleb revision with mitomycin C

MMC when applied topically or injected subconjunctivally, prevents proliferation of fibroblasts within the subconjunctival space and tenon’s capsule. It also has a lethal effect on vascular endothelial cells. A single application of MMC can cause localized, irreversible inhibition of both fibroblasts and vascular endothelial cells. MMC is estimated to be 100 times more potent than 5-FU in fibro...

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Revision of encapsulated blebs after trabeculectomy: Long-term comparison of standard bleb needling and modified needling procedure combined with transconjunctival scleral flap sutures

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The relationship of bleb morphology and the outcome of needle revision with 5-fluorouracil in failing filtering bleb

To investigate the risk factors for failure of needling revision with 5-fluorouracil (5-FU) and to identify the correlation of outcomes of needling revision and the morphological features of dysfunctional filtration blebs using Moorfields bleb grading system.This retrospective, nonrandomized, comparative case-control study included 41 consecutive patients (41 eyes) who underwent 5-FU needling r...

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[Filtering bleb after surgical cyclodialysis].

CASE REPORT A 35-year-old man with degenerative myopia suffered blunt ocular trauma due to being hit in the face by a ball. The injury caused four cyclodialysis clefts in his left eye which resulted in hypotony and chorioretinal folds. DISCUSSION The persisting hypotony was unsuccessfully treated with topical therapy and with laser photocoagulation. Therefore, a surgical treatment with direct...

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Needling revision with subconjunctival 5-fluorouracil in failing filtering blebs.

BACKGROUND 5-Fluorouracil, an antimetabolic agent, improves the success rate of trabeculectomies by inhibiting subconjunctival fibrosis. However, complications may be associated with early postoperative use. We investigated the outcome of needling revision with delayed subconjunctival 5-fluorouracil in failing filtering blebs after a trabeculectomy in patients with medically poorly controlled g...

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ژورنال

عنوان ژورنال: Graefe's Archive for Clinical and Experimental Ophthalmology

سال: 2021

ISSN: 0721-832X,1435-702X

DOI: 10.1007/s00417-021-05204-1